| pharmacodynamics | troxerutin is a better drug for the treatment of occlusive cerebrovascular disease. It can inhibit platelet aggregation and prevent thrombosis. At the same time, it can resist the vascular injury caused by serotonin and bradykinin, increase the Capillary resistance, reduce the capillary permeability, and prevent the edema caused by the increase of vascular permeability. Pharmacological experiments show that this product has a significant protective effect on acute ischemic brain injury. |
| Drug Action | troxerutin, also known as trioxyethyl rutin, trochopurine, vitamin P4, Hydroxyethyl rutin, it is a semi-synthetic flavonoid compound made of rutin by hydroxyethylation, which can inhibit the aggregation of red blood cells and platelets, prevent thrombosis, increase the content of oxygen in blood, improve microcirculation, and promote the formation of new blood vessels to Enhance collateral circulation. Has a protective effect on endothelial cells, can fight against serotonin and bradykinin-induced vascular injury, increase Capillary resistance, reduce capillary permeability, prevent edema caused by increased vascular permeability, have anti-radiation injury, anti-inflammatory, anti-allergic, anti-ulcer effects. Suitable for the treatment of cerebral thrombosis and cerebral embolism caused by hemiplegia, aphasia and myocardial infarction syndrome, arteriosclerosis, central retinitis, thrombophlebitis, varicose veins, edema caused by increased vascular permeability. |
| Clinical application | clinically applicable to cerebral thrombosis and cerebral embolism caused by hemiplegia, aphasia and preinfarction syndrome, arteriosclerosis, central retinitis, thrombophlebitis, varicose veins, edema caused by increased vascular permeability, etc. |
| indication | 1. This product can promote blood circulation to remove blood stasis, commonly used in the treatment of collaterals and blood stasis blockage of stroke. Notable for hemiplegia, numbness of hands and feet, strabismus of mouth and eyes, unfavourable language, drooling of mouth and coughing on drinking water. Patients with phlegm turbidity plus simvastatin or fenofibrate, hyperactivity of liver Yang plus captopril or propranolol, verapamil, etc., or plus ligustrazine or ozagrel, etc. to enhance blood circulation. 2. For chest pain. Can treat blood stasis blocking collaterals chest pain, palpitations. The patient was found to have chest tightness, heart palpitations, short breath, wheezing, restlessness and fear, cyanosis of cauda equina, petechiae of tongue and fine pulse. Can be combined with nitroglycerin, aspirin, etc., sputum turbidity plus simvastatin or fenofibrate. 3. Used for femoral swelling and blood stasis. This product can not only promote blood circulation, but also has the effect of dampness, and can also treat the above symptoms of blood stasis. Patients often have trauma, surgery or long-term history of bed rest, the disease showed limb swelling, pain, tenderness, skin redness, collateral dilation. 4. For trauma, after burn. This product can not only promote blood circulation, but also has the effect of water and dampness, which is helpful for local swelling to subside. |
| adverse reactions, contraindications and drug effects | This product may have gastrointestinal dysfunction and allergic reactions, individual intravenous drip administration can cause cardiovascular and liver toxicity, acute cerebral edema and arrhythmia, serious can produce temporary mental disorders, after stopping self-healing. If an allergic reaction occurs, the drug should be discontinued immediately. |
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